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Volume: 7, Issue: 1, January, 2017
DOI: 10.7324/JAPS.2017.70129

Research Article

Evaluation of Novel 4-Thiazolidinone-Based Derivatives as Possible Cytoprotective Agents against Stress Model in Rats

Iryna Ilkiv1, Roman Lesyk2, Olexandr Sklyarov1

  Author Affiliations


Multiple factors, such as increased intestinal barrier permeability, upregulation of iNOS/NO expression and decreased H2S synthesis are involved in the pathogenesis of inflammation. The purpose of this investigation was to explore the role of 4-thiazolidinone-based derivatives as a novel donors of H2S in promoting the resolution of inflammation in small intestine. In the present study, we investigated the effect of novel 4-thiazolidinone derivatives (compounds Les-5054 and Les-5055) on various intestinal events occurring in association with stress-induced gastrointestinal damage. It was observed an intensification of lipid peroxidation, myeloperoxidase activity, accompanied by increase of iNOS activity, NO production and decrease of H2S content in rats with water-immersion stress group. In animals treated with compounds Les-5054 and Les-5055 the reduction of the activity of iNOS, myeloperoxidase, intensity of lipid peroxidation and increased generation of H2S were revealed. 4-thiazolidinone-based derivatives increased small intestine mucosal activity of anti-oxidative enzymes SOD and catalase in rats subjected to stress. The compound Les-5054 showed significant efficacious effect and antioxidant properties compared to compound Les-5055.


Hydrogen sulfide, small intestine, water-immersion stress, 4-thiazolidinones.

Citation: Ilkiv I, Lesyk R, Sklyarov O. Evaluation of Novel 4- Thiazolidinone-Based Derivatives as Possible Cytoprotective Agents Against Stress Model In Rats. J App Pharm Sci, 2017; 7 (01): 199-203.

Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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