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Volume: 7, Issue: 1, January, 2017
DOI: 10.7324/JAPS.2017.70129



Research Article

Evaluation of Novel 4-Thiazolidinone-Based Derivatives as Possible Cytoprotective Agents against Stress Model in Rats

Iryna Ilkiv1, Roman Lesyk2, Olexandr Sklyarov1

  Author Affiliations


Abstract

Multiple factors, such as increased intestinal barrier permeability, upregulation of iNOS/NO expression and decreased H2S synthesis are involved in the pathogenesis of inflammation. The purpose of this investigation was to explore the role of 4-thiazolidinone-based derivatives as a novel donors of H2S in promoting the resolution of inflammation in small intestine. In the present study, we investigated the effect of novel 4-thiazolidinone derivatives (compounds Les-5054 and Les-5055) on various intestinal events occurring in association with stress-induced gastrointestinal damage. It was observed an intensification of lipid peroxidation, myeloperoxidase activity, accompanied by increase of iNOS activity, NO production and decrease of H2S content in rats with water-immersion stress group. In animals treated with compounds Les-5054 and Les-5055 the reduction of the activity of iNOS, myeloperoxidase, intensity of lipid peroxidation and increased generation of H2S were revealed. 4-thiazolidinone-based derivatives increased small intestine mucosal activity of anti-oxidative enzymes SOD and catalase in rats subjected to stress. The compound Les-5054 showed significant efficacious effect and antioxidant properties compared to compound Les-5055.

Keywords:

Hydrogen sulfide, small intestine, water-immersion stress, 4-thiazolidinones.


Citation: Ilkiv I, Lesyk R, Sklyarov O. Evaluation of Novel 4- Thiazolidinone-Based Derivatives as Possible Cytoprotective Agents Against Stress Model In Rats. J App Pharm Sci, 2017; 7 (01): 199-203.


Copyright: The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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